Message passing and Monte Carlo algorithms: connecting fixed points with metastable states

Mean field-like approximations (including naive mean field, Bethe and Kikuchi and more general Cluster Variational Methods) are known to stabilize ordered phases at temperatures higher than the thermodynamical transition. For example, in the Edwards-Anderson model in 2-dimensions these approximations predict a spin glass transition at finite $T$. Here we show that the spin glass solutions of the Cluster Variational Method (CVM) at plaquette level do describe well actual metastable states of the system. Moreover, we prove that these states can be used to predict non trivial statistical quantities, like the distribution of the overlap between two replicas. Our results support the idea that message passing algorithms can be helpful to accelerate Monte Carlo simulations in finite dimensional systems.Comment: 6 pages, 6 figure

Helioseismology and the solar age

The problem of measuring the solar age by means of helioseismology hasbeen recently revisited by Guenther & Demarque (1997) and by Weiss & Schlattl (1998). Different best values for $t_{\rm seis}$ and different assessment of the uncertainty resulted from these two works. We show that depending on the way seismic data are used, one may obtain the value $t_{\rm seis}\approx 4.6$ Gy, close to the age of the oldest meteorites, $t_{\rm met}=4.57$ Gy, like in the first paper, or above 5 Gy like in the second paper. The discrepancy in the seismic estimates of the solar age may be eliminated by assuming higher than the standard metal abundance and/or an upward revision of the opacities in the solar radiative interior.We argue that the most accurate and robust seismic measure of the solar age are the small frequency separations, $D_{\ell,n}=\nu_{l,n}-\nu_{\ell+1,n-1}$, for spherical harmonic degrees $\ell=0,2$ and radial orders $n\gg\ell$.The seismic age inferred by minimization of the sum of squared differences between the model and the solar small separations is $t_{\rm seis}=4.66\pm0.11$, a number consistent with meteoritic data.Our analysis supports earlier suggestions of using small frequency separations as stellar age indicators.Comment: 8 pages + 4 ps figures included, LaTeX file with l-aa.sty, submitted to Astronomy and Astrophysic

Addressing Item-Cold Start Problem in Recommendation Systems using Model Based Approach and Deep Learning

Traditional recommendation systems rely on past usage data in order to generate new recommendations. Those approaches fail to generate sensible recommendations for new users and items into the system due to missing information about their past interactions. In this paper, we propose a solution for successfully addressing item-cold start problem which uses model-based approach and recent advances in deep learning. In particular, we use latent factor model for recommendation, and predict the latent factors from item's descriptions using convolutional neural network when they cannot be obtained from usage data. Latent factors obtained by applying matrix factorization to the available usage data are used as ground truth to train the convolutional neural network. To create latent factor representations for the new items, the convolutional neural network uses their textual description. The results from the experiments reveal that the proposed approach significantly outperforms several baseline estimators

Strangeness Production in pp,pA,AA Interactions at SPS Energies.HIJING Approach

In this report we have made a systematic study of strangeness production in proton-proton(pp),proton-nucleus(pA) and nucleus- nucleus(AA) collisions at CERN Super Proton Synchroton energies, using$\,\,\, HIJING\,\,\, MONTE \,\,\,CARLO \,\,\,MODEL$ \\ (version $HIJ.01$). Numerical results for mean multiplicities of neutral strange particles ,as well as their ratios to negatives hadrons($$) for p-p,nucleon-nucleon(N-N),\,\,p-S,\,\,p-Ag,\,\,p-Au('min. bias')collisions and p-Au,\,\,S-S,\,\,S-Ag,\,\,S-Au ('central')collisions are compared to experimental data available from CERN experiments and also with recent theoretical estimations given by others models. Neutral strange particle abundances are quite well described for p-p,N-N and p-A interactions ,but are underpredicted by a factor of two in A-A interactions for $\Lambda,\bar{\Lambda}, K^{0}_{S}$ in symmetric collisions(S-S,\,\,Pb-Pb)and for $\Lambda,\bar{\Lambda}\,\,$in asymmetric ones(S-Ag,\,\,S-Au,\,\,S-W). A qualitative prediction for rapidity, transverse kinetic energy and transverse momenta normalized distributions are performed at 200 GeV/Nucleon in p-S,S-S,S-Ag and S-Au collisions in comparison with recent experimental data. HIJING model predictions for coming experiments at CERN for S-Au, S-W and Pb-Pb interactions are given. The theoretical calculations are estimated in a full phase space.Comment: 33 pages(LATEX),18 figures not included,available in hard copy upon request , Dipartamento di Fisica Padova,report DFPD-94-NP-4

Stellar archeology of the nearby LINER galaxies NGC 4579 and NGC 4736

Stellar archeology of nearby LINER galaxies may reveal if there is a stellar young population that may be responsible for the LINER phenomenon. We show results for the classical LINER galaxies NGC 4579 and NGC 4736 and find no evidence of such populations.Comment: 2 pages, 2 figures, to be published in the Proceedings of the IAU Symposium no. 26

Metronomic Chemotherapy with Vinorelbine Produces Clinical Benefit and Low Toxicity in Frail Elderly Patients Affected by Advanced Non-Small Cell Lung Cancer

Lung cancer is the leading cause of death worldwide. The treatment choice for advanced stage of lung cancer may depend on histotype, performance status (PS), age, and comorbidities. In the present study, we focused on the effect of metronomic vinorelbine treatment in elderly patients with advanced unresectable non-small cell lung cancer (NSCLC). Methods. From January 2016 to December 2016, 44 patients affected by non-small cell lung cancer referred to our oncology day hospital were progressively analyzed. The patients were treated with oral vinorelbine 30 mg x 3/wk or 40 mg x 3/wk meaning one day on and one day off. The patients were older than 60, stage IIIB or IV, ECOG PS ≥ 1, and have at least one important comorbidity (renal, hepatic, or cardiovascular disease). The schedule was based on ECOG-PS and comorbidities. The primary endpoint was progression-free survival (PFS). PFS was used to compare patients based on different scheduled dosage (30 or 40 mg x3/weekly) and age (more or less than 75 years old) as exploratory analysis. We also evaluated as secondary endpoint toxicity according to Common Toxicity Criteria Version 2.0. Results. Vinorelbine showed a good safety profile at different doses taken orally and was effective in controlling cancer progression. The median overall survival (OS) was 12 months. The disease control rate (DCR) achieved 63%. The median PFS was 9 months. A significant difference in PFS was detected comparing patients aged below with those over 75, and the HR value was 0.72 (p<0.05). Not significant was the difference between groups with different schedules. Conclusions. This study confirmed the safety profile of metronomic vinorelbine and its applicability for patients unfit for standard chemotherapies and adds the possibility of considering this type of schedule not only for very elderly patients

What information could the main actors of liquid biopsy provide? A representative case of non-small cell lung cancer (NSCLC)

In non-small cell lung cancer (NSCLC), there is a consensus regarding the use of liquid biopsy, generally, to detect "druggable" mutations and, in particular, to monitor tyrosine kinase inhibitor (TKI) treatments. However, whether circulating tumor cells (CTCs) are better tools than cell-free DNA (cfDNA), is still a matter of debate, mainly concerning which antigen(s) we should use to investigating simultaneously both epithelial and epithelial-to-mesenchymal transient (EMT) phenotype in the same sample of CTCs. To address this item, we exploited here a single-tube liquid biopsy, to detect both epithelial cell adhesion molecule (EpCAM)-positive CTCs and EpCAM-low/negative CTCs, because down-modulation of EpCAM is considered the first step in EMT. Furthermore, we analyzed the DNA from CTCs of four different phenotypes (ctcDNA), according to their EpCAM expression and cytokeratin pattern, and circulating tumor DNA (ctDNA) by droplet digital PCR (ddPCR), in order to disclose activating and resistancedriving mutations. Liquid biopsy reflected spatial and temporal heterogeneity of the tumor under treatment pressure. We provide the proof-of-concept that the complementary use of ctDNA and ctcDNA represents a reliable, minimally invasive and dynamic tool for a more comprehensive view of tumor evolution

Mapping low and high density clouds in astrophysical nebulae by imaging forbidden line emission

Emission line ratios have been essential for determining physical parameters such as gas temperature and density in astrophysical gaseous nebulae. With the advent of panoramic spectroscopic devices, images of regions with emission lines related to these physical parameters can, in principle, also be produced. We show that, with observations from modern instruments, it is possible to transform images taken from density sensitive forbidden lines into images of emission from high and low-density clouds by applying a transformation matrix. In order to achieve this, images of the pairs of density sensitive lines as well as the adjacent continuum have to be observed and combined. We have computed the critical densities for a series of pairs of lines in the infrared, optical, ultraviolet and X-rays bands, and calculated the pair line intensity ratios in the high and low-density limit using a 4 and 5 level atom approximation. In order to illustrate the method we applied it to GMOS-IFU data of two galactic nuclei. We conclude that this method provides new information of astrophysical interest, especially for mapping low and high-density clouds; for this reason we call it "the ld/hd imaging method".Comment: 7 pages, 4 figures, accepted for publication on MNRA